If you expect and enjoy the best of the best service, then experience luxury like no other in Murphysboro luxury properties. These grand hotels feature luxury and signature rooms as well as spacious king suites, Deluxe rooms with king beds and junior suites with sitting areas. Find the very best Murphysboro hotels that have excellent staff and services. Unwind in style at iconic luxury hotels in Murphysboro. These Murphysboro hotels offer luxurious accommodations with premium locations usually near main attractions. Check out this list of ultra-luxury Murphysboro hotels to pamper yourself. This is your source for everything from luxury vacation packages and Murphysboro getaways. Luxury hotels include five star resorts and boutique hotel gems in Murphysboro.